Prediction of Breast Cancer Risk Based on Profiling With Common Genetic Variants
Identifieur interne : 002980 ( Main/Exploration ); précédent : 002979; suivant : 002981Prediction of Breast Cancer Risk Based on Profiling With Common Genetic Variants
Auteurs : Nasim Mavaddat ; Paul D. P. Pharoah ; Kyriaki Michailidou ; Jonathan Tyrer ; Mark N. Brook ; Manjeet K. Bolla ; Qin Wang ; Joe Dennis ; Alison M. Dunning ; Mitul Shah ; Robert Luben ; Judith Brown ; Stig E. Bojesen ; B Rge G. Nordestgaard ; Sune F. Nielsen ; Henrik Flyger ; Kamila Czene ; Hatef Darabi ; Mikael Eriksson ; Julian Peto ; Isabel Dos-Santos-Silva ; Frank Dudbridge ; Nichola Johnson ; Marjanka K. Schmidt ; Annegien Broeks ; Senno Verhoef ; Emiel J. Rutgers ; Anthony Swerdlow ; Alan Ashworth ; Nick Orr ; Minouk J. Schoemaker ; Jonine Figueroa ; Stephen J. Chanock ; Louise Brinton ; Jolanta Lissowska ; Fergus J. Couch ; Janet E. Olson ; Celine Vachon ; Vernon S. Pankratz ; Diether Lambrechts ; Hans Wildiers ; Chantal Van Ongeval ; Erik Van Limbergen ; Vessela Kristensen ; Grethe Grenaker Aln S ; Silje Nord ; Anne-Lise Borresen-Dale ; Heli Nevanlinna ; Taru A. Muranen ; Kristiina Aittom Ki ; Carl Blomqvist ; Jenny Chang-Claude ; Anja Rudolph ; Petra Seibold ; Dieter Flesch-Janys ; Peter A. Fasching ; Lothar Haeberle ; Arif B. Ekici ; Matthias W. Beckmann ; Barbara Burwinkel ; Frederik Marme ; Andreas Schneeweiss ; Christof Sohn ; Amy Trentham-Dietz ; Polly Newcomb ; Linda Titus ; Kathleen M. Egan ; David J. Hunter ; Sara Lindstrom ; Rulla M. Tamimi ; Peter Kraft ; Nazneen Rahman ; Clare Turnbull ; Anthony Renwick ; Sheila Seal ; Jingmei Li ; Jianjun Liu ; Keith Humphreys ; Javier Benitez ; M. Pilar Zamora ; Jose Ignacio Arias Perez ; Primitiva Menéndez ; Anna Jakubowska ; Jan Lubinski ; Katarzyna Jaworska-Bieniek ; Katarzyna Durda ; Natalia V. Bogdanova ; Natalia N. Antonenkova ; Thilo Dörk ; Hoda Anton-Culver ; Susan L. Neuhausen ; Argyrios Ziogas ; Leslie Bernstein ; Peter Devilee ; Robert A. E. M. Tollenaar ; Caroline Seynaeve ; Christi J. Van Asperen ; Angela Cox ; Simon S. Cross ; Malcolm W. R. Reed ; Elza Khusnutdinova ; Marina Bermisheva ; Darya Prokofyeva ; Zalina Takhirova ; Alfons Meindl ; Rita K. Schmutzler ; Christian Sutter ; Rongxi Yang ; Peter Schürmann ; Michael Bremer ; Hans Christiansen ; Tjoung-Won Park-Simon ; Peter Hillemanns ; Pascal Guénel ; Thérèse Truong ; Florence Menegaux ; Marie Sanchez ; Paolo Radice ; Paolo Peterlongo ; Siranoush Manoukian ; Valeria Pensotti ; John L. Hopper ; Helen Tsimiklis ; Carmel Apicella ; Melissa C. Southey ; Hiltrud Brauch ; Thomas Brüning ; Yon-Dschun Ko ; Alice J. Sigurdson ; Michele M. Doody ; Ute Hamann ; Diana Torres ; Hans-Ulrich Ulmer ; Asta Försti ; Elinor J. Sawyer ; Ian Tomlinson ; Michael J. Kerin ; Nicola Miller ; Irene L. Andrulis ; Julia A. Knight ; Gord Glendon ; Anna Marie Mulligan ; Georgia Chenevix-Trench ; Rosemary Balleine ; Graham G. Giles ; Roger L. Milne ; Catriona Mclean ; Annika Lindblom ; Sara Margolin ; Christopher A. Haiman ; Brian E. Henderson ; Fredrick Schumacher ; Loic Le Marchand ; Ursula Eilber ; Shan Wang-Gohrke ; Maartje J. Hooning ; Antoinette Hollestelle ; Ans M. W. Van Den Ouweland ; Linetta B. Koppert ; Jane Carpenter ; Christine Clarke ; Rodney Scott ; Arto Mannermaa ; Vesa Kataja ; Veli-Matti Kosma ; Jaana M. Hartikainen ; Hermann Brenner ; Volker Arndt ; Christa Stegmaier ; Aida Karina Dieffenbach ; Robert Winqvist ; Katri Pylk S ; Arja Jukkola-Vuorinen ; Mervi Grip ; Kenneth Offit ; Joseph Vijai ; Mark Robson ; Rohini Rau-Murthy ; Miriam Dwek ; Ruth Swann ; Katherine Annie Perkins ; Mark S. Goldberg ; France Labrèche ; Martine Dumont ; Diana M. Eccles ; William J. Tapper ; Sajjad Rafiq ; Esther M. John ; Alice S. Whittemore ; Susan Slager ; Drakoulis Yannoukakos ; Amanda E. Toland ; Song Yao ; Wei Zheng ; Sandra L. Halverson ; Anna González-Neira ; Guillermo Pita ; M. Rosario Alonso ; Nuria Álvarez ; Daniel Herrero ; Daniel C. Tessier ; Daniel Vincent ; Francois Bacot ; Craig Luccarini ; Caroline Baynes ; Shahana Ahmed ; Mel Maranian ; Catherine S. Healey ; Jacques Simard ; Per Hall ; Douglas F. Easton ; Montserrat Garcia-ClosasSource :
- JNCI Journal of the National Cancer Institute [ 0027-8874 ] ; 2015.
Abstract
Data for multiple common susceptibility alleles for breast cancer may be combined to identify women at different levels of breast cancer risk. Such stratification could guide preventive and screening strategies. However, empirical evidence for genetic risk stratification is lacking.
We investigated the value of using 77 breast cancer-associated single nucleotide polymorphisms (SNPs) for risk stratification, in a study of 33 673 breast cancer cases and 33 381 control women of European origin. We tested all possible pair-wise multiplicative interactions and constructed a 77-SNP polygenic risk score (PRS) for breast cancer overall and by estrogen receptor (ER) status. Absolute risks of breast cancer by PRS were derived from relative risk estimates and UK incidence and mortality rates.
There was no strong evidence for departure from a multiplicative model for any SNP pair. Women in the highest 1% of the PRS had a three-fold increased risk of developing breast cancer compared with women in the middle quintile (odds ratio [OR] = 3.36, 95% confidence interval [CI] = 2.95 to 3.83). The ORs for ER-positive and ER-negative disease were 3.73 (95% CI = 3.24 to 4.30) and 2.80 (95% CI = 2.26 to 3.46), respectively. Lifetime risk of breast cancer for women in the lowest and highest quintiles of the PRS were 5.2% and 16.6% for a woman without family history, and 8.6% and 24.4% for a woman with a first-degree family history of breast cancer.
The PRS stratifies breast cancer risk in women both with and without a family history of breast cancer. The observed level of risk discrimination could inform targeted screening and prevention strategies. Further discrimination may be achievable through combining the PRS with lifestyle/environmental factors, although these were not considered in this report.
Url:
DOI: 10.1093/jnci/djv036
PubMed: 25855707
PubMed Central: 4754625
Affiliations:
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Bogdanova</name></author><author><name sortKey="Antonenkova, Natalia N" sort="Antonenkova, Natalia N" uniqKey="Antonenkova N" first="Natalia N." last="Antonenkova">Natalia N. Antonenkova</name></author><author><name sortKey="Dork, Thilo" sort="Dork, Thilo" uniqKey="Dork T" first="Thilo" last="Dörk">Thilo Dörk</name></author><author><name sortKey="Anton Culver, Hoda" sort="Anton Culver, Hoda" uniqKey="Anton Culver H" first="Hoda" last="Anton-Culver">Hoda Anton-Culver</name></author><author><name sortKey="Neuhausen, Susan L" sort="Neuhausen, Susan L" uniqKey="Neuhausen S" first="Susan L." last="Neuhausen">Susan L. 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Van Asperen</name></author><author><name sortKey="Cox, Angela" sort="Cox, Angela" uniqKey="Cox A" first="Angela" last="Cox">Angela Cox</name></author><author><name sortKey="Cross, Simon S" sort="Cross, Simon S" uniqKey="Cross S" first="Simon S." last="Cross">Simon S. Cross</name></author><author><name sortKey="Reed, Malcolm W R" sort="Reed, Malcolm W R" uniqKey="Reed M" first="Malcolm W. R." last="Reed">Malcolm W. R. Reed</name></author><author><name sortKey="Khusnutdinova, Elza" sort="Khusnutdinova, Elza" uniqKey="Khusnutdinova E" first="Elza" last="Khusnutdinova">Elza Khusnutdinova</name></author><author><name sortKey="Bermisheva, Marina" sort="Bermisheva, Marina" uniqKey="Bermisheva M" first="Marina" last="Bermisheva">Marina Bermisheva</name></author><author><name sortKey="Prokofyeva, Darya" sort="Prokofyeva, Darya" uniqKey="Prokofyeva D" first="Darya" last="Prokofyeva">Darya Prokofyeva</name></author><author><name sortKey="Takhirova, Zalina" sort="Takhirova, Zalina" uniqKey="Takhirova Z" first="Zalina" last="Takhirova">Zalina Takhirova</name></author><author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name></author><author><name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K." last="Schmutzler">Rita K. Schmutzler</name></author><author><name sortKey="Sutter, Christian" sort="Sutter, Christian" uniqKey="Sutter C" first="Christian" last="Sutter">Christian Sutter</name></author><author><name sortKey="Yang, Rongxi" sort="Yang, Rongxi" uniqKey="Yang R" first="Rongxi" last="Yang">Rongxi Yang</name></author><author><name sortKey="Schurmann, Peter" sort="Schurmann, Peter" uniqKey="Schurmann P" first="Peter" last="Schürmann">Peter Schürmann</name></author><author><name sortKey="Bremer, Michael" sort="Bremer, Michael" uniqKey="Bremer M" first="Michael" last="Bremer">Michael Bremer</name></author><author><name sortKey="Christiansen, Hans" sort="Christiansen, Hans" uniqKey="Christiansen H" first="Hans" last="Christiansen">Hans Christiansen</name></author><author><name sortKey="Park Simon, Tjoung Won" sort="Park Simon, Tjoung Won" uniqKey="Park Simon T" first="Tjoung-Won" last="Park-Simon">Tjoung-Won Park-Simon</name></author><author><name sortKey="Hillemanns, Peter" sort="Hillemanns, Peter" uniqKey="Hillemanns P" first="Peter" last="Hillemanns">Peter Hillemanns</name></author><author><name sortKey="Guenel, Pascal" sort="Guenel, Pascal" uniqKey="Guenel P" first="Pascal" last="Guénel">Pascal Guénel</name></author><author><name sortKey="Truong, Therese" sort="Truong, Therese" uniqKey="Truong T" first="Thérèse" last="Truong">Thérèse Truong</name></author><author><name sortKey="Menegaux, Florence" sort="Menegaux, Florence" uniqKey="Menegaux F" first="Florence" last="Menegaux">Florence Menegaux</name></author><author><name sortKey="Sanchez, Marie" sort="Sanchez, Marie" uniqKey="Sanchez M" first="Marie" last="Sanchez">Marie Sanchez</name></author><author><name sortKey="Radice, Paolo" sort="Radice, Paolo" uniqKey="Radice P" first="Paolo" last="Radice">Paolo Radice</name></author><author><name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name></author><author><name sortKey="Manoukian, Siranoush" sort="Manoukian, Siranoush" uniqKey="Manoukian S" first="Siranoush" last="Manoukian">Siranoush Manoukian</name></author><author><name sortKey="Pensotti, Valeria" sort="Pensotti, Valeria" uniqKey="Pensotti V" first="Valeria" last="Pensotti">Valeria Pensotti</name></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name></author><author><name sortKey="Tsimiklis, Helen" sort="Tsimiklis, Helen" uniqKey="Tsimiklis H" first="Helen" last="Tsimiklis">Helen Tsimiklis</name></author><author><name sortKey="Apicella, Carmel" sort="Apicella, Carmel" uniqKey="Apicella C" first="Carmel" last="Apicella">Carmel Apicella</name></author><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C." last="Southey">Melissa C. Southey</name></author><author><name sortKey="Brauch, Hiltrud" sort="Brauch, Hiltrud" uniqKey="Brauch H" first="Hiltrud" last="Brauch">Hiltrud Brauch</name></author><author><name sortKey="Bruning, Thomas" sort="Bruning, Thomas" uniqKey="Bruning T" first="Thomas" last="Brüning">Thomas Brüning</name></author><author><name sortKey="Ko, Yon Dschun" sort="Ko, Yon Dschun" uniqKey="Ko Y" first="Yon-Dschun" last="Ko">Yon-Dschun Ko</name></author><author><name sortKey="Sigurdson, Alice J" sort="Sigurdson, Alice J" uniqKey="Sigurdson A" first="Alice J." last="Sigurdson">Alice J. Sigurdson</name></author><author><name sortKey="Doody, Michele M" sort="Doody, Michele M" uniqKey="Doody M" first="Michele M." last="Doody">Michele M. Doody</name></author><author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name></author><author><name sortKey="Torres, Diana" sort="Torres, Diana" uniqKey="Torres D" first="Diana" last="Torres">Diana Torres</name></author><author><name sortKey="Ulmer, Hans Ulrich" sort="Ulmer, Hans Ulrich" uniqKey="Ulmer H" first="Hans-Ulrich" last="Ulmer">Hans-Ulrich Ulmer</name></author><author><name sortKey="Forsti, Asta" sort="Forsti, Asta" uniqKey="Forsti A" first="Asta" last="Försti">Asta Försti</name></author><author><name sortKey="Sawyer, Elinor J" sort="Sawyer, Elinor J" uniqKey="Sawyer E" first="Elinor J." last="Sawyer">Elinor J. Sawyer</name></author><author><name sortKey="Tomlinson, Ian" sort="Tomlinson, Ian" uniqKey="Tomlinson I" first="Ian" last="Tomlinson">Ian Tomlinson</name></author><author><name sortKey="Kerin, Michael J" sort="Kerin, Michael J" uniqKey="Kerin M" first="Michael J." last="Kerin">Michael J. Kerin</name></author><author><name sortKey="Miller, Nicola" sort="Miller, Nicola" uniqKey="Miller N" first="Nicola" last="Miller">Nicola Miller</name></author><author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name></author><author><name sortKey="Knight, Julia A" sort="Knight, Julia A" uniqKey="Knight J" first="Julia A." last="Knight">Julia A. Knight</name></author><author><name sortKey="Glendon, Gord" sort="Glendon, Gord" uniqKey="Glendon G" first="Gord" last="Glendon">Gord Glendon</name></author><author><name sortKey="Marie Mulligan, Anna" sort="Marie Mulligan, Anna" uniqKey="Marie Mulligan A" first="Anna" last="Marie Mulligan">Anna Marie Mulligan</name></author><author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name></author><author><name sortKey="Balleine, Rosemary" sort="Balleine, Rosemary" uniqKey="Balleine R" first="Rosemary" last="Balleine">Rosemary Balleine</name></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name></author><author><name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L." last="Milne">Roger L. Milne</name></author><author><name sortKey="Mclean, Catriona" sort="Mclean, Catriona" uniqKey="Mclean C" first="Catriona" last="Mclean">Catriona Mclean</name></author><author><name sortKey="Lindblom, Annika" sort="Lindblom, Annika" uniqKey="Lindblom A" first="Annika" last="Lindblom">Annika Lindblom</name></author><author><name sortKey="Margolin, Sara" sort="Margolin, Sara" uniqKey="Margolin S" first="Sara" last="Margolin">Sara Margolin</name></author><author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A." last="Haiman">Christopher A. Haiman</name></author><author><name sortKey="Henderson, Brian E" sort="Henderson, Brian E" uniqKey="Henderson B" first="Brian E." last="Henderson">Brian E. Henderson</name></author><author><name sortKey="Schumacher, Fredrick" sort="Schumacher, Fredrick" uniqKey="Schumacher F" first="Fredrick" last="Schumacher">Fredrick Schumacher</name></author><author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name></author><author><name sortKey="Eilber, Ursula" sort="Eilber, Ursula" uniqKey="Eilber U" first="Ursula" last="Eilber">Ursula Eilber</name></author><author><name sortKey="Wang Gohrke, Shan" sort="Wang Gohrke, Shan" uniqKey="Wang Gohrke S" first="Shan" last="Wang-Gohrke">Shan Wang-Gohrke</name></author><author><name sortKey="Hooning, Maartje J" sort="Hooning, Maartje J" uniqKey="Hooning M" first="Maartje J." last="Hooning">Maartje J. Hooning</name></author><author><name sortKey="Hollestelle, Antoinette" sort="Hollestelle, Antoinette" uniqKey="Hollestelle A" first="Antoinette" last="Hollestelle">Antoinette Hollestelle</name></author><author><name sortKey="Van Den Ouweland, Ans M W" sort="Van Den Ouweland, Ans M W" uniqKey="Van Den Ouweland A" first="Ans M. W." last="Van Den Ouweland">Ans M. W. Van Den Ouweland</name></author><author><name sortKey="Koppert, Linetta B" sort="Koppert, Linetta B" uniqKey="Koppert L" first="Linetta B." last="Koppert">Linetta B. Koppert</name></author><author><name sortKey="Carpenter, Jane" sort="Carpenter, Jane" uniqKey="Carpenter J" first="Jane" last="Carpenter">Jane Carpenter</name></author><author><name sortKey="Clarke, Christine" sort="Clarke, Christine" uniqKey="Clarke C" first="Christine" last="Clarke">Christine Clarke</name></author><author><name sortKey="Scott, Rodney" sort="Scott, Rodney" uniqKey="Scott R" first="Rodney" last="Scott">Rodney Scott</name></author><author><name sortKey="Mannermaa, Arto" sort="Mannermaa, Arto" uniqKey="Mannermaa A" first="Arto" last="Mannermaa">Arto Mannermaa</name></author><author><name sortKey="Kataja, Vesa" sort="Kataja, Vesa" uniqKey="Kataja V" first="Vesa" last="Kataja">Vesa Kataja</name></author><author><name sortKey="Kosma, Veli Matti" sort="Kosma, Veli Matti" uniqKey="Kosma V" first="Veli-Matti" last="Kosma">Veli-Matti Kosma</name></author><author><name sortKey="Hartikainen, Jaana M" sort="Hartikainen, Jaana M" uniqKey="Hartikainen J" first="Jaana M." last="Hartikainen">Jaana M. Hartikainen</name></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name></author><author><name sortKey="Arndt, Volker" sort="Arndt, Volker" uniqKey="Arndt V" first="Volker" last="Arndt">Volker Arndt</name></author><author><name sortKey="Stegmaier, Christa" sort="Stegmaier, Christa" uniqKey="Stegmaier C" first="Christa" last="Stegmaier">Christa Stegmaier</name></author><author><name sortKey="Karina Dieffenbach, Aida" sort="Karina Dieffenbach, Aida" uniqKey="Karina Dieffenbach A" first="Aida" last="Karina Dieffenbach">Aida Karina Dieffenbach</name></author><author><name sortKey="Winqvist, Robert" sort="Winqvist, Robert" uniqKey="Winqvist R" first="Robert" last="Winqvist">Robert Winqvist</name></author><author><name sortKey="Pylk S, Katri" sort="Pylk S, Katri" uniqKey="Pylk S K" first="Katri" last="Pylk S">Katri Pylk S</name></author><author><name sortKey="Jukkola Vuorinen, Arja" sort="Jukkola Vuorinen, Arja" uniqKey="Jukkola Vuorinen A" first="Arja" last="Jukkola-Vuorinen">Arja Jukkola-Vuorinen</name></author><author><name sortKey="Grip, Mervi" sort="Grip, Mervi" uniqKey="Grip M" first="Mervi" last="Grip">Mervi Grip</name></author><author><name sortKey="Offit, Kenneth" sort="Offit, Kenneth" uniqKey="Offit K" first="Kenneth" last="Offit">Kenneth Offit</name></author><author><name sortKey="Vijai, Joseph" sort="Vijai, Joseph" uniqKey="Vijai J" first="Joseph" last="Vijai">Joseph Vijai</name></author><author><name sortKey="Robson, Mark" sort="Robson, Mark" uniqKey="Robson M" first="Mark" last="Robson">Mark Robson</name></author><author><name sortKey="Rau Murthy, Rohini" sort="Rau Murthy, Rohini" uniqKey="Rau Murthy R" first="Rohini" last="Rau-Murthy">Rohini Rau-Murthy</name></author><author><name sortKey="Dwek, Miriam" sort="Dwek, Miriam" uniqKey="Dwek M" first="Miriam" last="Dwek">Miriam Dwek</name></author><author><name sortKey="Swann, Ruth" sort="Swann, Ruth" uniqKey="Swann R" first="Ruth" last="Swann">Ruth Swann</name></author><author><name sortKey="Annie Perkins, Katherine" sort="Annie Perkins, Katherine" uniqKey="Annie Perkins K" first="Katherine" last="Annie Perkins">Katherine Annie Perkins</name></author><author><name sortKey="Goldberg, Mark S" sort="Goldberg, Mark S" uniqKey="Goldberg M" first="Mark S." last="Goldberg">Mark S. Goldberg</name></author><author><name sortKey="Labreche, France" sort="Labreche, France" uniqKey="Labreche F" first="France" last="Labrèche">France Labrèche</name></author><author><name sortKey="Dumont, Martine" sort="Dumont, Martine" uniqKey="Dumont M" first="Martine" last="Dumont">Martine Dumont</name></author><author><name sortKey="Eccles, Diana M" sort="Eccles, Diana M" uniqKey="Eccles D" first="Diana M." last="Eccles">Diana M. Eccles</name></author><author><name sortKey="Tapper, William J" sort="Tapper, William J" uniqKey="Tapper W" first="William J." last="Tapper">William J. Tapper</name></author><author><name sortKey="Rafiq, Sajjad" sort="Rafiq, Sajjad" uniqKey="Rafiq S" first="Sajjad" last="Rafiq">Sajjad Rafiq</name></author><author><name sortKey="John, Esther M" sort="John, Esther M" uniqKey="John E" first="Esther M." last="John">Esther M. John</name></author><author><name sortKey="Whittemore, Alice S" sort="Whittemore, Alice S" uniqKey="Whittemore A" first="Alice S." last="Whittemore">Alice S. Whittemore</name></author><author><name sortKey="Slager, Susan" sort="Slager, Susan" uniqKey="Slager S" first="Susan" last="Slager">Susan Slager</name></author><author><name sortKey="Yannoukakos, Drakoulis" sort="Yannoukakos, Drakoulis" uniqKey="Yannoukakos D" first="Drakoulis" last="Yannoukakos">Drakoulis Yannoukakos</name></author><author><name sortKey="Toland, Amanda E" sort="Toland, Amanda E" uniqKey="Toland A" first="Amanda E." last="Toland">Amanda E. Toland</name></author><author><name sortKey="Yao, Song" sort="Yao, Song" uniqKey="Yao S" first="Song" last="Yao">Song Yao</name></author><author><name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name></author><author><name sortKey="Halverson, Sandra L" sort="Halverson, Sandra L" uniqKey="Halverson S" first="Sandra L." last="Halverson">Sandra L. Halverson</name></author><author><name sortKey="Gonzalez Neira, Anna" sort="Gonzalez Neira, Anna" uniqKey="Gonzalez Neira A" first="Anna" last="González-Neira">Anna González-Neira</name></author><author><name sortKey="Pita, Guillermo" sort="Pita, Guillermo" uniqKey="Pita G" first="Guillermo" last="Pita">Guillermo Pita</name></author><author><name sortKey="Rosario Alonso, M" sort="Rosario Alonso, M" uniqKey="Rosario Alonso M" first="M." last="Rosario Alonso">M. 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Tessier</name></author><author><name sortKey="Vincent, Daniel" sort="Vincent, Daniel" uniqKey="Vincent D" first="Daniel" last="Vincent">Daniel Vincent</name></author><author><name sortKey="Bacot, Francois" sort="Bacot, Francois" uniqKey="Bacot F" first="Francois" last="Bacot">Francois Bacot</name></author><author><name sortKey="Luccarini, Craig" sort="Luccarini, Craig" uniqKey="Luccarini C" first="Craig" last="Luccarini">Craig Luccarini</name></author><author><name sortKey="Baynes, Caroline" sort="Baynes, Caroline" uniqKey="Baynes C" first="Caroline" last="Baynes">Caroline Baynes</name></author><author><name sortKey="Ahmed, Shahana" sort="Ahmed, Shahana" uniqKey="Ahmed S" first="Shahana" last="Ahmed">Shahana Ahmed</name></author><author><name sortKey="Maranian, Mel" sort="Maranian, Mel" uniqKey="Maranian M" first="Mel" last="Maranian">Mel Maranian</name></author><author><name sortKey="Healey, Catherine S" sort="Healey, Catherine S" uniqKey="Healey C" first="Catherine S." last="Healey">Catherine S. Healey</name></author><author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name></author><author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name></author><author><name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="Garcia-Closas">Montserrat Garcia-Closas</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25855707</idno><idno type="pmc">4754625</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754625</idno><idno type="RBID">PMC:4754625</idno><idno type="doi">10.1093/jnci/djv036</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000559</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000559</idno><idno type="wicri:Area/Pmc/Curation">000559</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000559</idno><idno type="wicri:Area/Pmc/Checkpoint">000D84</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000D84</idno><idno type="wicri:Area/Ncbi/Merge">002430</idno><idno type="wicri:Area/Ncbi/Curation">002430</idno><idno type="wicri:Area/Ncbi/Checkpoint">002430</idno><idno type="wicri:doubleKey">0027-8874:2015:Mavaddat N:prediction:of:breast</idno><idno type="wicri:Area/Main/Merge">002980</idno><idno type="wicri:Area/Main/Curation">002980</idno><idno type="wicri:Area/Main/Exploration">002980</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Prediction of Breast Cancer Risk Based on Profiling With Common Genetic Variants</title><author><name sortKey="Mavaddat, Nasim" sort="Mavaddat, Nasim" uniqKey="Mavaddat N" first="Nasim" last="Mavaddat">Nasim Mavaddat</name></author><author><name sortKey="Pharoah, Paul D P" sort="Pharoah, Paul D P" uniqKey="Pharoah P" first="Paul D. P." last="Pharoah">Paul D. P. Pharoah</name></author><author><name sortKey="Michailidou, Kyriaki" sort="Michailidou, Kyriaki" uniqKey="Michailidou K" first="Kyriaki" last="Michailidou">Kyriaki Michailidou</name></author><author><name sortKey="Tyrer, Jonathan" sort="Tyrer, Jonathan" uniqKey="Tyrer J" first="Jonathan" last="Tyrer">Jonathan Tyrer</name></author><author><name sortKey="Brook, Mark N" sort="Brook, Mark N" uniqKey="Brook M" first="Mark N." last="Brook">Mark N. Brook</name></author><author><name sortKey="Bolla, Manjeet K" sort="Bolla, Manjeet K" uniqKey="Bolla M" first="Manjeet K." last="Bolla">Manjeet K. Bolla</name></author><author><name sortKey="Wang, Qin" sort="Wang, Qin" uniqKey="Wang Q" first="Qin" last="Wang">Qin Wang</name></author><author><name sortKey="Dennis, Joe" sort="Dennis, Joe" uniqKey="Dennis J" first="Joe" last="Dennis">Joe Dennis</name></author><author><name sortKey="Dunning, Alison M" sort="Dunning, Alison M" uniqKey="Dunning A" first="Alison M." last="Dunning">Alison M. Dunning</name></author><author><name sortKey="Shah, Mitul" sort="Shah, Mitul" uniqKey="Shah M" first="Mitul" last="Shah">Mitul Shah</name></author><author><name sortKey="Luben, Robert" sort="Luben, Robert" uniqKey="Luben R" first="Robert" last="Luben">Robert Luben</name></author><author><name sortKey="Brown, Judith" sort="Brown, Judith" uniqKey="Brown J" first="Judith" last="Brown">Judith Brown</name></author><author><name sortKey="Bojesen, Stig E" sort="Bojesen, Stig E" uniqKey="Bojesen S" first="Stig E." last="Bojesen">Stig E. Bojesen</name></author><author><name sortKey="Nordestgaard, B Rge G" sort="Nordestgaard, B Rge G" uniqKey="Nordestgaard B" first="B Rge G." last="Nordestgaard">B Rge G. Nordestgaard</name></author><author><name sortKey="Nielsen, Sune F" sort="Nielsen, Sune F" uniqKey="Nielsen S" first="Sune F." last="Nielsen">Sune F. Nielsen</name></author><author><name sortKey="Flyger, Henrik" sort="Flyger, Henrik" uniqKey="Flyger H" first="Henrik" last="Flyger">Henrik Flyger</name></author><author><name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name></author><author><name sortKey="Darabi, Hatef" sort="Darabi, Hatef" uniqKey="Darabi H" first="Hatef" last="Darabi">Hatef Darabi</name></author><author><name sortKey="Eriksson, Mikael" sort="Eriksson, Mikael" uniqKey="Eriksson M" first="Mikael" last="Eriksson">Mikael Eriksson</name></author><author><name sortKey="Peto, Julian" sort="Peto, Julian" uniqKey="Peto J" first="Julian" last="Peto">Julian Peto</name></author><author><name sortKey="Dos Santos Silva, Isabel" sort="Dos Santos Silva, Isabel" uniqKey="Dos Santos Silva I" first="Isabel" last="Dos-Santos-Silva">Isabel Dos-Santos-Silva</name></author><author><name sortKey="Dudbridge, Frank" sort="Dudbridge, Frank" uniqKey="Dudbridge F" first="Frank" last="Dudbridge">Frank Dudbridge</name></author><author><name sortKey="Johnson, Nichola" sort="Johnson, Nichola" uniqKey="Johnson N" first="Nichola" last="Johnson">Nichola Johnson</name></author><author><name sortKey="Schmidt, Marjanka K" sort="Schmidt, Marjanka K" uniqKey="Schmidt M" first="Marjanka K." last="Schmidt">Marjanka K. Schmidt</name></author><author><name sortKey="Broeks, Annegien" sort="Broeks, Annegien" uniqKey="Broeks A" first="Annegien" last="Broeks">Annegien Broeks</name></author><author><name sortKey="Verhoef, Senno" sort="Verhoef, Senno" uniqKey="Verhoef S" first="Senno" last="Verhoef">Senno Verhoef</name></author><author><name sortKey="Rutgers, Emiel J" sort="Rutgers, Emiel J" uniqKey="Rutgers E" first="Emiel J." last="Rutgers">Emiel J. Rutgers</name></author><author><name sortKey="Swerdlow, Anthony" sort="Swerdlow, Anthony" uniqKey="Swerdlow A" first="Anthony" last="Swerdlow">Anthony Swerdlow</name></author><author><name sortKey="Ashworth, Alan" sort="Ashworth, Alan" uniqKey="Ashworth A" first="Alan" last="Ashworth">Alan Ashworth</name></author><author><name sortKey="Orr, Nick" sort="Orr, Nick" uniqKey="Orr N" first="Nick" last="Orr">Nick Orr</name></author><author><name sortKey="Schoemaker, Minouk J" sort="Schoemaker, Minouk J" uniqKey="Schoemaker M" first="Minouk J." last="Schoemaker">Minouk J. Schoemaker</name></author><author><name sortKey="Figueroa, Jonine" sort="Figueroa, Jonine" uniqKey="Figueroa J" first="Jonine" last="Figueroa">Jonine Figueroa</name></author><author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J." last="Chanock">Stephen J. Chanock</name></author><author><name sortKey="Brinton, Louise" sort="Brinton, Louise" uniqKey="Brinton L" first="Louise" last="Brinton">Louise Brinton</name></author><author><name sortKey="Lissowska, Jolanta" sort="Lissowska, Jolanta" uniqKey="Lissowska J" first="Jolanta" last="Lissowska">Jolanta Lissowska</name></author><author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name></author><author><name sortKey="Olson, Janet E" sort="Olson, Janet E" uniqKey="Olson J" first="Janet E." last="Olson">Janet E. Olson</name></author><author><name sortKey="Vachon, Celine" sort="Vachon, Celine" uniqKey="Vachon C" first="Celine" last="Vachon">Celine Vachon</name></author><author><name sortKey="Pankratz, Vernon S" sort="Pankratz, Vernon S" uniqKey="Pankratz V" first="Vernon S." last="Pankratz">Vernon S. Pankratz</name></author><author><name sortKey="Lambrechts, Diether" sort="Lambrechts, Diether" uniqKey="Lambrechts D" first="Diether" last="Lambrechts">Diether Lambrechts</name></author><author><name sortKey="Wildiers, Hans" sort="Wildiers, Hans" uniqKey="Wildiers H" first="Hans" last="Wildiers">Hans Wildiers</name></author><author><name sortKey="Van Ongeval, Chantal" sort="Van Ongeval, Chantal" uniqKey="Van Ongeval C" first="Chantal" last="Van Ongeval">Chantal Van Ongeval</name></author><author><name sortKey="Van Limbergen, Erik" sort="Van Limbergen, Erik" uniqKey="Van Limbergen E" first="Erik" last="Van Limbergen">Erik Van Limbergen</name></author><author><name sortKey="Kristensen, Vessela" sort="Kristensen, Vessela" uniqKey="Kristensen V" first="Vessela" last="Kristensen">Vessela Kristensen</name></author><author><name sortKey="Grenaker Aln S, Grethe" sort="Grenaker Aln S, Grethe" uniqKey="Grenaker Aln S G" first="Grethe" last="Grenaker Aln S">Grethe Grenaker Aln S</name></author><author><name sortKey="Nord, Silje" sort="Nord, Silje" uniqKey="Nord S" first="Silje" last="Nord">Silje Nord</name></author><author><name sortKey="Borresen Dale, Anne Lise" sort="Borresen Dale, Anne Lise" uniqKey="Borresen Dale A" first="Anne-Lise" last="Borresen-Dale">Anne-Lise Borresen-Dale</name></author><author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name></author><author><name sortKey="Muranen, Taru A" sort="Muranen, Taru A" uniqKey="Muranen T" first="Taru A." last="Muranen">Taru A. Muranen</name></author><author><name sortKey="Aittom Ki, Kristiina" sort="Aittom Ki, Kristiina" uniqKey="Aittom Ki K" first="Kristiina" last="Aittom Ki">Kristiina Aittom Ki</name></author><author><name sortKey="Blomqvist, Carl" sort="Blomqvist, Carl" uniqKey="Blomqvist C" first="Carl" last="Blomqvist">Carl Blomqvist</name></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name></author><author><name sortKey="Rudolph, Anja" sort="Rudolph, Anja" uniqKey="Rudolph A" first="Anja" last="Rudolph">Anja Rudolph</name></author><author><name sortKey="Seibold, Petra" sort="Seibold, Petra" uniqKey="Seibold P" first="Petra" last="Seibold">Petra Seibold</name></author><author><name sortKey="Flesch Janys, Dieter" sort="Flesch Janys, Dieter" uniqKey="Flesch Janys D" first="Dieter" last="Flesch-Janys">Dieter Flesch-Janys</name></author><author><name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A." last="Fasching">Peter A. Fasching</name></author><author><name sortKey="Haeberle, Lothar" sort="Haeberle, Lothar" uniqKey="Haeberle L" first="Lothar" last="Haeberle">Lothar Haeberle</name></author><author><name sortKey="Ekici, Arif B" sort="Ekici, Arif B" uniqKey="Ekici A" first="Arif B." last="Ekici">Arif B. Ekici</name></author><author><name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W." last="Beckmann">Matthias W. Beckmann</name></author><author><name sortKey="Burwinkel, Barbara" sort="Burwinkel, Barbara" uniqKey="Burwinkel B" first="Barbara" last="Burwinkel">Barbara Burwinkel</name></author><author><name sortKey="Marme, Frederik" sort="Marme, Frederik" uniqKey="Marme F" first="Frederik" last="Marme">Frederik Marme</name></author><author><name sortKey="Schneeweiss, Andreas" sort="Schneeweiss, Andreas" uniqKey="Schneeweiss A" first="Andreas" last="Schneeweiss">Andreas Schneeweiss</name></author><author><name sortKey="Sohn, Christof" sort="Sohn, Christof" uniqKey="Sohn C" first="Christof" last="Sohn">Christof Sohn</name></author><author><name sortKey="Trentham Dietz, Amy" sort="Trentham Dietz, Amy" uniqKey="Trentham Dietz A" first="Amy" last="Trentham-Dietz">Amy Trentham-Dietz</name></author><author><name sortKey="Newcomb, Polly" sort="Newcomb, Polly" uniqKey="Newcomb P" first="Polly" last="Newcomb">Polly Newcomb</name></author><author><name sortKey="Titus, Linda" sort="Titus, Linda" uniqKey="Titus L" first="Linda" last="Titus">Linda Titus</name></author><author><name sortKey="Egan, Kathleen M" sort="Egan, Kathleen M" uniqKey="Egan K" first="Kathleen M." last="Egan">Kathleen M. Egan</name></author><author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J." last="Hunter">David J. Hunter</name></author><author><name sortKey="Lindstrom, Sara" sort="Lindstrom, Sara" uniqKey="Lindstrom S" first="Sara" last="Lindstrom">Sara Lindstrom</name></author><author><name sortKey="Tamimi, Rulla M" sort="Tamimi, Rulla M" uniqKey="Tamimi R" first="Rulla M." last="Tamimi">Rulla M. Tamimi</name></author><author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name></author><author><name sortKey="Rahman, Nazneen" sort="Rahman, Nazneen" uniqKey="Rahman N" first="Nazneen" last="Rahman">Nazneen Rahman</name></author><author><name sortKey="Turnbull, Clare" sort="Turnbull, Clare" uniqKey="Turnbull C" first="Clare" last="Turnbull">Clare Turnbull</name></author><author><name sortKey="Renwick, Anthony" sort="Renwick, Anthony" uniqKey="Renwick A" first="Anthony" last="Renwick">Anthony Renwick</name></author><author><name sortKey="Seal, Sheila" sort="Seal, Sheila" uniqKey="Seal S" first="Sheila" last="Seal">Sheila Seal</name></author><author><name sortKey="Li, Jingmei" sort="Li, Jingmei" uniqKey="Li J" first="Jingmei" last="Li">Jingmei Li</name></author><author><name sortKey="Liu, Jianjun" sort="Liu, Jianjun" uniqKey="Liu J" first="Jianjun" last="Liu">Jianjun Liu</name></author><author><name sortKey="Humphreys, Keith" sort="Humphreys, Keith" uniqKey="Humphreys K" first="Keith" last="Humphreys">Keith Humphreys</name></author><author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benitez">Javier Benitez</name></author><author><name sortKey="Pilar Zamora, M" sort="Pilar Zamora, M" uniqKey="Pilar Zamora M" first="M." last="Pilar Zamora">M. Pilar Zamora</name></author><author><name sortKey="Arias Perez, Jose Ignacio" sort="Arias Perez, Jose Ignacio" uniqKey="Arias Perez J" first="Jose Ignacio" last="Arias Perez">Jose Ignacio Arias Perez</name></author><author><name sortKey="Menendez, Primitiva" sort="Menendez, Primitiva" uniqKey="Menendez P" first="Primitiva" last="Menéndez">Primitiva Menéndez</name></author><author><name sortKey="Jakubowska, Anna" sort="Jakubowska, Anna" uniqKey="Jakubowska A" first="Anna" last="Jakubowska">Anna Jakubowska</name></author><author><name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name></author><author><name sortKey="Jaworska Bieniek, Katarzyna" sort="Jaworska Bieniek, Katarzyna" uniqKey="Jaworska Bieniek K" first="Katarzyna" last="Jaworska-Bieniek">Katarzyna Jaworska-Bieniek</name></author><author><name sortKey="Durda, Katarzyna" sort="Durda, Katarzyna" uniqKey="Durda K" first="Katarzyna" last="Durda">Katarzyna Durda</name></author><author><name sortKey="Bogdanova, Natalia V" sort="Bogdanova, Natalia V" uniqKey="Bogdanova N" first="Natalia V." last="Bogdanova">Natalia V. Bogdanova</name></author><author><name sortKey="Antonenkova, Natalia N" sort="Antonenkova, Natalia N" uniqKey="Antonenkova N" first="Natalia N." last="Antonenkova">Natalia N. Antonenkova</name></author><author><name sortKey="Dork, Thilo" sort="Dork, Thilo" uniqKey="Dork T" first="Thilo" last="Dörk">Thilo Dörk</name></author><author><name sortKey="Anton Culver, Hoda" sort="Anton Culver, Hoda" uniqKey="Anton Culver H" first="Hoda" last="Anton-Culver">Hoda Anton-Culver</name></author><author><name sortKey="Neuhausen, Susan L" sort="Neuhausen, Susan L" uniqKey="Neuhausen S" first="Susan L." last="Neuhausen">Susan L. Neuhausen</name></author><author><name sortKey="Ziogas, Argyrios" sort="Ziogas, Argyrios" uniqKey="Ziogas A" first="Argyrios" last="Ziogas">Argyrios Ziogas</name></author><author><name sortKey="Bernstein, Leslie" sort="Bernstein, Leslie" uniqKey="Bernstein L" first="Leslie" last="Bernstein">Leslie Bernstein</name></author><author><name sortKey="Devilee, Peter" sort="Devilee, Peter" uniqKey="Devilee P" first="Peter" last="Devilee">Peter Devilee</name></author><author><name sortKey="Tollenaar, Robert A E M" sort="Tollenaar, Robert A E M" uniqKey="Tollenaar R" first="Robert A. E. M." last="Tollenaar">Robert A. E. M. Tollenaar</name></author><author><name sortKey="Seynaeve, Caroline" sort="Seynaeve, Caroline" uniqKey="Seynaeve C" first="Caroline" last="Seynaeve">Caroline Seynaeve</name></author><author><name sortKey="Van Asperen, Christi J" sort="Van Asperen, Christi J" uniqKey="Van Asperen C" first="Christi J." last="Van Asperen">Christi J. Van Asperen</name></author><author><name sortKey="Cox, Angela" sort="Cox, Angela" uniqKey="Cox A" first="Angela" last="Cox">Angela Cox</name></author><author><name sortKey="Cross, Simon S" sort="Cross, Simon S" uniqKey="Cross S" first="Simon S." last="Cross">Simon S. Cross</name></author><author><name sortKey="Reed, Malcolm W R" sort="Reed, Malcolm W R" uniqKey="Reed M" first="Malcolm W. R." last="Reed">Malcolm W. R. Reed</name></author><author><name sortKey="Khusnutdinova, Elza" sort="Khusnutdinova, Elza" uniqKey="Khusnutdinova E" first="Elza" last="Khusnutdinova">Elza Khusnutdinova</name></author><author><name sortKey="Bermisheva, Marina" sort="Bermisheva, Marina" uniqKey="Bermisheva M" first="Marina" last="Bermisheva">Marina Bermisheva</name></author><author><name sortKey="Prokofyeva, Darya" sort="Prokofyeva, Darya" uniqKey="Prokofyeva D" first="Darya" last="Prokofyeva">Darya Prokofyeva</name></author><author><name sortKey="Takhirova, Zalina" sort="Takhirova, Zalina" uniqKey="Takhirova Z" first="Zalina" last="Takhirova">Zalina Takhirova</name></author><author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name></author><author><name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K." last="Schmutzler">Rita K. Schmutzler</name></author><author><name sortKey="Sutter, Christian" sort="Sutter, Christian" uniqKey="Sutter C" first="Christian" last="Sutter">Christian Sutter</name></author><author><name sortKey="Yang, Rongxi" sort="Yang, Rongxi" uniqKey="Yang R" first="Rongxi" last="Yang">Rongxi Yang</name></author><author><name sortKey="Schurmann, Peter" sort="Schurmann, Peter" uniqKey="Schurmann P" first="Peter" last="Schürmann">Peter Schürmann</name></author><author><name sortKey="Bremer, Michael" sort="Bremer, Michael" uniqKey="Bremer M" first="Michael" last="Bremer">Michael Bremer</name></author><author><name sortKey="Christiansen, Hans" sort="Christiansen, Hans" uniqKey="Christiansen H" first="Hans" last="Christiansen">Hans Christiansen</name></author><author><name sortKey="Park Simon, Tjoung Won" sort="Park Simon, Tjoung Won" uniqKey="Park Simon T" first="Tjoung-Won" last="Park-Simon">Tjoung-Won Park-Simon</name></author><author><name sortKey="Hillemanns, Peter" sort="Hillemanns, Peter" uniqKey="Hillemanns P" first="Peter" last="Hillemanns">Peter Hillemanns</name></author><author><name sortKey="Guenel, Pascal" sort="Guenel, Pascal" uniqKey="Guenel P" first="Pascal" last="Guénel">Pascal Guénel</name></author><author><name sortKey="Truong, Therese" sort="Truong, Therese" uniqKey="Truong T" first="Thérèse" last="Truong">Thérèse Truong</name></author><author><name sortKey="Menegaux, Florence" sort="Menegaux, Florence" uniqKey="Menegaux F" first="Florence" last="Menegaux">Florence Menegaux</name></author><author><name sortKey="Sanchez, Marie" sort="Sanchez, Marie" uniqKey="Sanchez M" first="Marie" last="Sanchez">Marie Sanchez</name></author><author><name sortKey="Radice, Paolo" sort="Radice, Paolo" uniqKey="Radice P" first="Paolo" last="Radice">Paolo Radice</name></author><author><name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name></author><author><name sortKey="Manoukian, Siranoush" sort="Manoukian, Siranoush" uniqKey="Manoukian S" first="Siranoush" last="Manoukian">Siranoush Manoukian</name></author><author><name sortKey="Pensotti, Valeria" sort="Pensotti, Valeria" uniqKey="Pensotti V" first="Valeria" last="Pensotti">Valeria Pensotti</name></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name></author><author><name sortKey="Tsimiklis, Helen" sort="Tsimiklis, Helen" uniqKey="Tsimiklis H" first="Helen" last="Tsimiklis">Helen Tsimiklis</name></author><author><name sortKey="Apicella, Carmel" sort="Apicella, Carmel" uniqKey="Apicella C" first="Carmel" last="Apicella">Carmel Apicella</name></author><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C." last="Southey">Melissa C. Southey</name></author><author><name sortKey="Brauch, Hiltrud" sort="Brauch, Hiltrud" uniqKey="Brauch H" first="Hiltrud" last="Brauch">Hiltrud Brauch</name></author><author><name sortKey="Bruning, Thomas" sort="Bruning, Thomas" uniqKey="Bruning T" first="Thomas" last="Brüning">Thomas Brüning</name></author><author><name sortKey="Ko, Yon Dschun" sort="Ko, Yon Dschun" uniqKey="Ko Y" first="Yon-Dschun" last="Ko">Yon-Dschun Ko</name></author><author><name sortKey="Sigurdson, Alice J" sort="Sigurdson, Alice J" uniqKey="Sigurdson A" first="Alice J." last="Sigurdson">Alice J. Sigurdson</name></author><author><name sortKey="Doody, Michele M" sort="Doody, Michele M" uniqKey="Doody M" first="Michele M." last="Doody">Michele M. Doody</name></author><author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name></author><author><name sortKey="Torres, Diana" sort="Torres, Diana" uniqKey="Torres D" first="Diana" last="Torres">Diana Torres</name></author><author><name sortKey="Ulmer, Hans Ulrich" sort="Ulmer, Hans Ulrich" uniqKey="Ulmer H" first="Hans-Ulrich" last="Ulmer">Hans-Ulrich Ulmer</name></author><author><name sortKey="Forsti, Asta" sort="Forsti, Asta" uniqKey="Forsti A" first="Asta" last="Försti">Asta Försti</name></author><author><name sortKey="Sawyer, Elinor J" sort="Sawyer, Elinor J" uniqKey="Sawyer E" first="Elinor J." last="Sawyer">Elinor J. Sawyer</name></author><author><name sortKey="Tomlinson, Ian" sort="Tomlinson, Ian" uniqKey="Tomlinson I" first="Ian" last="Tomlinson">Ian Tomlinson</name></author><author><name sortKey="Kerin, Michael J" sort="Kerin, Michael J" uniqKey="Kerin M" first="Michael J." last="Kerin">Michael J. Kerin</name></author><author><name sortKey="Miller, Nicola" sort="Miller, Nicola" uniqKey="Miller N" first="Nicola" last="Miller">Nicola Miller</name></author><author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name></author><author><name sortKey="Knight, Julia A" sort="Knight, Julia A" uniqKey="Knight J" first="Julia A." last="Knight">Julia A. Knight</name></author><author><name sortKey="Glendon, Gord" sort="Glendon, Gord" uniqKey="Glendon G" first="Gord" last="Glendon">Gord Glendon</name></author><author><name sortKey="Marie Mulligan, Anna" sort="Marie Mulligan, Anna" uniqKey="Marie Mulligan A" first="Anna" last="Marie Mulligan">Anna Marie Mulligan</name></author><author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name></author><author><name sortKey="Balleine, Rosemary" sort="Balleine, Rosemary" uniqKey="Balleine R" first="Rosemary" last="Balleine">Rosemary Balleine</name></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name></author><author><name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L." last="Milne">Roger L. Milne</name></author><author><name sortKey="Mclean, Catriona" sort="Mclean, Catriona" uniqKey="Mclean C" first="Catriona" last="Mclean">Catriona Mclean</name></author><author><name sortKey="Lindblom, Annika" sort="Lindblom, Annika" uniqKey="Lindblom A" first="Annika" last="Lindblom">Annika Lindblom</name></author><author><name sortKey="Margolin, Sara" sort="Margolin, Sara" uniqKey="Margolin S" first="Sara" last="Margolin">Sara Margolin</name></author><author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A." last="Haiman">Christopher A. Haiman</name></author><author><name sortKey="Henderson, Brian E" sort="Henderson, Brian E" uniqKey="Henderson B" first="Brian E." last="Henderson">Brian E. Henderson</name></author><author><name sortKey="Schumacher, Fredrick" sort="Schumacher, Fredrick" uniqKey="Schumacher F" first="Fredrick" last="Schumacher">Fredrick Schumacher</name></author><author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name></author><author><name sortKey="Eilber, Ursula" sort="Eilber, Ursula" uniqKey="Eilber U" first="Ursula" last="Eilber">Ursula Eilber</name></author><author><name sortKey="Wang Gohrke, Shan" sort="Wang Gohrke, Shan" uniqKey="Wang Gohrke S" first="Shan" last="Wang-Gohrke">Shan Wang-Gohrke</name></author><author><name sortKey="Hooning, Maartje J" sort="Hooning, Maartje J" uniqKey="Hooning M" first="Maartje J." last="Hooning">Maartje J. Hooning</name></author><author><name sortKey="Hollestelle, Antoinette" sort="Hollestelle, Antoinette" uniqKey="Hollestelle A" first="Antoinette" last="Hollestelle">Antoinette Hollestelle</name></author><author><name sortKey="Van Den Ouweland, Ans M W" sort="Van Den Ouweland, Ans M W" uniqKey="Van Den Ouweland A" first="Ans M. W." last="Van Den Ouweland">Ans M. W. Van Den Ouweland</name></author><author><name sortKey="Koppert, Linetta B" sort="Koppert, Linetta B" uniqKey="Koppert L" first="Linetta B." last="Koppert">Linetta B. Koppert</name></author><author><name sortKey="Carpenter, Jane" sort="Carpenter, Jane" uniqKey="Carpenter J" first="Jane" last="Carpenter">Jane Carpenter</name></author><author><name sortKey="Clarke, Christine" sort="Clarke, Christine" uniqKey="Clarke C" first="Christine" last="Clarke">Christine Clarke</name></author><author><name sortKey="Scott, Rodney" sort="Scott, Rodney" uniqKey="Scott R" first="Rodney" last="Scott">Rodney Scott</name></author><author><name sortKey="Mannermaa, Arto" sort="Mannermaa, Arto" uniqKey="Mannermaa A" first="Arto" last="Mannermaa">Arto Mannermaa</name></author><author><name sortKey="Kataja, Vesa" sort="Kataja, Vesa" uniqKey="Kataja V" first="Vesa" last="Kataja">Vesa Kataja</name></author><author><name sortKey="Kosma, Veli Matti" sort="Kosma, Veli Matti" uniqKey="Kosma V" first="Veli-Matti" last="Kosma">Veli-Matti Kosma</name></author><author><name sortKey="Hartikainen, Jaana M" sort="Hartikainen, Jaana M" uniqKey="Hartikainen J" first="Jaana M." last="Hartikainen">Jaana M. Hartikainen</name></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name></author><author><name sortKey="Arndt, Volker" sort="Arndt, Volker" uniqKey="Arndt V" first="Volker" last="Arndt">Volker Arndt</name></author><author><name sortKey="Stegmaier, Christa" sort="Stegmaier, Christa" uniqKey="Stegmaier C" first="Christa" last="Stegmaier">Christa Stegmaier</name></author><author><name sortKey="Karina Dieffenbach, Aida" sort="Karina Dieffenbach, Aida" uniqKey="Karina Dieffenbach A" first="Aida" last="Karina Dieffenbach">Aida Karina Dieffenbach</name></author><author><name sortKey="Winqvist, Robert" sort="Winqvist, Robert" uniqKey="Winqvist R" first="Robert" last="Winqvist">Robert Winqvist</name></author><author><name sortKey="Pylk S, Katri" sort="Pylk S, Katri" uniqKey="Pylk S K" first="Katri" last="Pylk S">Katri Pylk S</name></author><author><name sortKey="Jukkola Vuorinen, Arja" sort="Jukkola Vuorinen, Arja" uniqKey="Jukkola Vuorinen A" first="Arja" last="Jukkola-Vuorinen">Arja Jukkola-Vuorinen</name></author><author><name sortKey="Grip, Mervi" sort="Grip, Mervi" uniqKey="Grip M" first="Mervi" last="Grip">Mervi Grip</name></author><author><name sortKey="Offit, Kenneth" sort="Offit, Kenneth" uniqKey="Offit K" first="Kenneth" last="Offit">Kenneth Offit</name></author><author><name sortKey="Vijai, Joseph" sort="Vijai, Joseph" uniqKey="Vijai J" first="Joseph" last="Vijai">Joseph Vijai</name></author><author><name sortKey="Robson, Mark" sort="Robson, Mark" uniqKey="Robson M" first="Mark" last="Robson">Mark Robson</name></author><author><name sortKey="Rau Murthy, Rohini" sort="Rau Murthy, Rohini" uniqKey="Rau Murthy R" first="Rohini" last="Rau-Murthy">Rohini Rau-Murthy</name></author><author><name sortKey="Dwek, Miriam" sort="Dwek, Miriam" uniqKey="Dwek M" first="Miriam" last="Dwek">Miriam Dwek</name></author><author><name sortKey="Swann, Ruth" sort="Swann, Ruth" uniqKey="Swann R" first="Ruth" last="Swann">Ruth Swann</name></author><author><name sortKey="Annie Perkins, Katherine" sort="Annie Perkins, Katherine" uniqKey="Annie Perkins K" first="Katherine" last="Annie Perkins">Katherine Annie Perkins</name></author><author><name sortKey="Goldberg, Mark S" sort="Goldberg, Mark S" uniqKey="Goldberg M" first="Mark S." last="Goldberg">Mark S. Goldberg</name></author><author><name sortKey="Labreche, France" sort="Labreche, France" uniqKey="Labreche F" first="France" last="Labrèche">France Labrèche</name></author><author><name sortKey="Dumont, Martine" sort="Dumont, Martine" uniqKey="Dumont M" first="Martine" last="Dumont">Martine Dumont</name></author><author><name sortKey="Eccles, Diana M" sort="Eccles, Diana M" uniqKey="Eccles D" first="Diana M." last="Eccles">Diana M. Eccles</name></author><author><name sortKey="Tapper, William J" sort="Tapper, William J" uniqKey="Tapper W" first="William J." last="Tapper">William J. Tapper</name></author><author><name sortKey="Rafiq, Sajjad" sort="Rafiq, Sajjad" uniqKey="Rafiq S" first="Sajjad" last="Rafiq">Sajjad Rafiq</name></author><author><name sortKey="John, Esther M" sort="John, Esther M" uniqKey="John E" first="Esther M." last="John">Esther M. John</name></author><author><name sortKey="Whittemore, Alice S" sort="Whittemore, Alice S" uniqKey="Whittemore A" first="Alice S." last="Whittemore">Alice S. Whittemore</name></author><author><name sortKey="Slager, Susan" sort="Slager, Susan" uniqKey="Slager S" first="Susan" last="Slager">Susan Slager</name></author><author><name sortKey="Yannoukakos, Drakoulis" sort="Yannoukakos, Drakoulis" uniqKey="Yannoukakos D" first="Drakoulis" last="Yannoukakos">Drakoulis Yannoukakos</name></author><author><name sortKey="Toland, Amanda E" sort="Toland, Amanda E" uniqKey="Toland A" first="Amanda E." last="Toland">Amanda E. Toland</name></author><author><name sortKey="Yao, Song" sort="Yao, Song" uniqKey="Yao S" first="Song" last="Yao">Song Yao</name></author><author><name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name></author><author><name sortKey="Halverson, Sandra L" sort="Halverson, Sandra L" uniqKey="Halverson S" first="Sandra L." last="Halverson">Sandra L. Halverson</name></author><author><name sortKey="Gonzalez Neira, Anna" sort="Gonzalez Neira, Anna" uniqKey="Gonzalez Neira A" first="Anna" last="González-Neira">Anna González-Neira</name></author><author><name sortKey="Pita, Guillermo" sort="Pita, Guillermo" uniqKey="Pita G" first="Guillermo" last="Pita">Guillermo Pita</name></author><author><name sortKey="Rosario Alonso, M" sort="Rosario Alonso, M" uniqKey="Rosario Alonso M" first="M." last="Rosario Alonso">M. Rosario Alonso</name></author><author><name sortKey="Alvarez, Nuria" sort="Alvarez, Nuria" uniqKey="Alvarez N" first="Nuria" last="Álvarez">Nuria Álvarez</name></author><author><name sortKey="Herrero, Daniel" sort="Herrero, Daniel" uniqKey="Herrero D" first="Daniel" last="Herrero">Daniel Herrero</name></author><author><name sortKey="Tessier, Daniel C" sort="Tessier, Daniel C" uniqKey="Tessier D" first="Daniel C." last="Tessier">Daniel C. Tessier</name></author><author><name sortKey="Vincent, Daniel" sort="Vincent, Daniel" uniqKey="Vincent D" first="Daniel" last="Vincent">Daniel Vincent</name></author><author><name sortKey="Bacot, Francois" sort="Bacot, Francois" uniqKey="Bacot F" first="Francois" last="Bacot">Francois Bacot</name></author><author><name sortKey="Luccarini, Craig" sort="Luccarini, Craig" uniqKey="Luccarini C" first="Craig" last="Luccarini">Craig Luccarini</name></author><author><name sortKey="Baynes, Caroline" sort="Baynes, Caroline" uniqKey="Baynes C" first="Caroline" last="Baynes">Caroline Baynes</name></author><author><name sortKey="Ahmed, Shahana" sort="Ahmed, Shahana" uniqKey="Ahmed S" first="Shahana" last="Ahmed">Shahana Ahmed</name></author><author><name sortKey="Maranian, Mel" sort="Maranian, Mel" uniqKey="Maranian M" first="Mel" last="Maranian">Mel Maranian</name></author><author><name sortKey="Healey, Catherine S" sort="Healey, Catherine S" uniqKey="Healey C" first="Catherine S." last="Healey">Catherine S. Healey</name></author><author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name></author><author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name></author><author><name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="Garcia-Closas">Montserrat Garcia-Closas</name></author></analytic><series><title level="j">JNCI Journal of the National Cancer Institute</title><idno type="ISSN">0027-8874</idno><idno type="eISSN">1460-2105</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background:</title><p>Data for multiple common susceptibility alleles for breast cancer may be combined to identify women at different levels of breast cancer risk. Such stratification could guide preventive and screening strategies. However, empirical evidence for genetic risk stratification is lacking.</p></sec><sec><title>Methods:</title><p>We investigated the value of using 77 breast cancer-associated single nucleotide polymorphisms (SNPs) for risk stratification, in a study of 33 673 breast cancer cases and 33 381 control women of European origin. We tested all possible pair-wise multiplicative interactions and constructed a 77-SNP polygenic risk score (PRS) for breast cancer overall and by estrogen receptor (ER) status. Absolute risks of breast cancer by PRS were derived from relative risk estimates and UK incidence and mortality rates.</p></sec><sec><title>Results:</title><p>There was no strong evidence for departure from a multiplicative model for any SNP pair. Women in the highest 1% of the PRS had a three-fold increased risk of developing breast cancer compared with women in the middle quintile (odds ratio [OR] = 3.36, 95% confidence interval [CI] = 2.95 to 3.83). The ORs for ER-positive and ER-negative disease were 3.73 (95% CI = 3.24 to 4.30) and 2.80 (95% CI = 2.26 to 3.46), respectively. Lifetime risk of breast cancer for women in the lowest and highest quintiles of the PRS were 5.2% and 16.6% for a woman without family history, and 8.6% and 24.4% for a woman with a first-degree family history of breast cancer.</p></sec><sec><title>Conclusions:</title><p>The PRS stratifies breast cancer risk in women both with and without a family history of breast cancer. The observed level of risk discrimination could inform targeted screening and prevention strategies. 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Andrulis</name><name sortKey="Annie Perkins, Katherine" sort="Annie Perkins, Katherine" uniqKey="Annie Perkins K" first="Katherine" last="Annie Perkins">Katherine Annie Perkins</name><name sortKey="Anton Culver, Hoda" sort="Anton Culver, Hoda" uniqKey="Anton Culver H" first="Hoda" last="Anton-Culver">Hoda Anton-Culver</name><name sortKey="Antonenkova, Natalia N" sort="Antonenkova, Natalia N" uniqKey="Antonenkova N" first="Natalia N." last="Antonenkova">Natalia N. Antonenkova</name><name sortKey="Apicella, Carmel" sort="Apicella, Carmel" uniqKey="Apicella C" first="Carmel" last="Apicella">Carmel Apicella</name><name sortKey="Arias Perez, Jose Ignacio" sort="Arias Perez, Jose Ignacio" uniqKey="Arias Perez J" first="Jose Ignacio" last="Arias Perez">Jose Ignacio Arias Perez</name><name sortKey="Arndt, Volker" sort="Arndt, Volker" uniqKey="Arndt V" first="Volker" last="Arndt">Volker Arndt</name><name sortKey="Ashworth, Alan" sort="Ashworth, Alan" uniqKey="Ashworth A" first="Alan" last="Ashworth">Alan Ashworth</name><name sortKey="Bacot, Francois" sort="Bacot, Francois" uniqKey="Bacot F" first="Francois" last="Bacot">Francois Bacot</name><name sortKey="Balleine, Rosemary" sort="Balleine, Rosemary" uniqKey="Balleine R" first="Rosemary" last="Balleine">Rosemary Balleine</name><name sortKey="Baynes, Caroline" sort="Baynes, Caroline" uniqKey="Baynes C" first="Caroline" last="Baynes">Caroline Baynes</name><name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W." last="Beckmann">Matthias W. Beckmann</name><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benitez">Javier Benitez</name><name sortKey="Bermisheva, Marina" sort="Bermisheva, Marina" uniqKey="Bermisheva M" first="Marina" last="Bermisheva">Marina Bermisheva</name><name sortKey="Bernstein, Leslie" sort="Bernstein, Leslie" uniqKey="Bernstein L" first="Leslie" last="Bernstein">Leslie Bernstein</name><name sortKey="Blomqvist, Carl" sort="Blomqvist, Carl" uniqKey="Blomqvist C" first="Carl" last="Blomqvist">Carl Blomqvist</name><name sortKey="Bogdanova, Natalia V" sort="Bogdanova, Natalia V" uniqKey="Bogdanova N" first="Natalia V." last="Bogdanova">Natalia V. Bogdanova</name><name sortKey="Bojesen, Stig E" sort="Bojesen, Stig E" uniqKey="Bojesen S" first="Stig E." last="Bojesen">Stig E. Bojesen</name><name sortKey="Bolla, Manjeet K" sort="Bolla, Manjeet K" uniqKey="Bolla M" first="Manjeet K." last="Bolla">Manjeet K. Bolla</name><name sortKey="Borresen Dale, Anne Lise" sort="Borresen Dale, Anne Lise" uniqKey="Borresen Dale A" first="Anne-Lise" last="Borresen-Dale">Anne-Lise Borresen-Dale</name><name sortKey="Brauch, Hiltrud" sort="Brauch, Hiltrud" uniqKey="Brauch H" first="Hiltrud" last="Brauch">Hiltrud Brauch</name><name sortKey="Bremer, Michael" sort="Bremer, Michael" uniqKey="Bremer M" first="Michael" last="Bremer">Michael Bremer</name><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><name sortKey="Brinton, Louise" sort="Brinton, Louise" uniqKey="Brinton L" first="Louise" last="Brinton">Louise Brinton</name><name sortKey="Broeks, Annegien" sort="Broeks, Annegien" uniqKey="Broeks A" first="Annegien" last="Broeks">Annegien Broeks</name><name sortKey="Brook, Mark N" sort="Brook, Mark N" uniqKey="Brook M" first="Mark N." last="Brook">Mark N. Brook</name><name sortKey="Brown, Judith" sort="Brown, Judith" uniqKey="Brown J" first="Judith" last="Brown">Judith Brown</name><name sortKey="Bruning, Thomas" sort="Bruning, Thomas" uniqKey="Bruning T" first="Thomas" last="Brüning">Thomas Brüning</name><name sortKey="Burwinkel, Barbara" sort="Burwinkel, Barbara" uniqKey="Burwinkel B" first="Barbara" last="Burwinkel">Barbara Burwinkel</name><name sortKey="Carpenter, Jane" sort="Carpenter, Jane" uniqKey="Carpenter J" first="Jane" last="Carpenter">Jane Carpenter</name><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J." last="Chanock">Stephen J. Chanock</name><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name><name sortKey="Christiansen, Hans" sort="Christiansen, Hans" uniqKey="Christiansen H" first="Hans" last="Christiansen">Hans Christiansen</name><name sortKey="Clarke, Christine" sort="Clarke, Christine" uniqKey="Clarke C" first="Christine" last="Clarke">Christine Clarke</name><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name><name sortKey="Cox, Angela" sort="Cox, Angela" uniqKey="Cox A" first="Angela" last="Cox">Angela Cox</name><name sortKey="Cross, Simon S" sort="Cross, Simon S" uniqKey="Cross S" first="Simon S." last="Cross">Simon S. Cross</name><name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name><name sortKey="Darabi, Hatef" sort="Darabi, Hatef" uniqKey="Darabi H" first="Hatef" last="Darabi">Hatef Darabi</name><name sortKey="Dennis, Joe" sort="Dennis, Joe" uniqKey="Dennis J" first="Joe" last="Dennis">Joe Dennis</name><name sortKey="Devilee, Peter" sort="Devilee, Peter" uniqKey="Devilee P" first="Peter" last="Devilee">Peter Devilee</name><name sortKey="Doody, Michele M" sort="Doody, Michele M" uniqKey="Doody M" first="Michele M." last="Doody">Michele M. Doody</name><name sortKey="Dork, Thilo" sort="Dork, Thilo" uniqKey="Dork T" first="Thilo" last="Dörk">Thilo Dörk</name><name sortKey="Dos Santos Silva, Isabel" sort="Dos Santos Silva, Isabel" uniqKey="Dos Santos Silva I" first="Isabel" last="Dos-Santos-Silva">Isabel Dos-Santos-Silva</name><name sortKey="Dudbridge, Frank" sort="Dudbridge, Frank" uniqKey="Dudbridge F" first="Frank" last="Dudbridge">Frank Dudbridge</name><name sortKey="Dumont, Martine" sort="Dumont, Martine" uniqKey="Dumont M" first="Martine" last="Dumont">Martine Dumont</name><name sortKey="Dunning, Alison M" sort="Dunning, Alison M" uniqKey="Dunning A" first="Alison M." last="Dunning">Alison M. Dunning</name><name sortKey="Durda, Katarzyna" sort="Durda, Katarzyna" uniqKey="Durda K" first="Katarzyna" last="Durda">Katarzyna Durda</name><name sortKey="Dwek, Miriam" sort="Dwek, Miriam" uniqKey="Dwek M" first="Miriam" last="Dwek">Miriam Dwek</name><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name><name sortKey="Eccles, Diana M" sort="Eccles, Diana M" uniqKey="Eccles D" first="Diana M." last="Eccles">Diana M. Eccles</name><name sortKey="Egan, Kathleen M" sort="Egan, Kathleen M" uniqKey="Egan K" first="Kathleen M." last="Egan">Kathleen M. Egan</name><name sortKey="Eilber, Ursula" sort="Eilber, Ursula" uniqKey="Eilber U" first="Ursula" last="Eilber">Ursula Eilber</name><name sortKey="Ekici, Arif B" sort="Ekici, Arif B" uniqKey="Ekici A" first="Arif B." last="Ekici">Arif B. Ekici</name><name sortKey="Eriksson, Mikael" sort="Eriksson, Mikael" uniqKey="Eriksson M" first="Mikael" last="Eriksson">Mikael Eriksson</name><name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A." last="Fasching">Peter A. Fasching</name><name sortKey="Figueroa, Jonine" sort="Figueroa, Jonine" uniqKey="Figueroa J" first="Jonine" last="Figueroa">Jonine Figueroa</name><name sortKey="Flesch Janys, Dieter" sort="Flesch Janys, Dieter" uniqKey="Flesch Janys D" first="Dieter" last="Flesch-Janys">Dieter Flesch-Janys</name><name sortKey="Flyger, Henrik" sort="Flyger, Henrik" uniqKey="Flyger H" first="Henrik" last="Flyger">Henrik Flyger</name><name sortKey="Forsti, Asta" sort="Forsti, Asta" uniqKey="Forsti A" first="Asta" last="Försti">Asta Försti</name><name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="Garcia-Closas">Montserrat Garcia-Closas</name><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name><name sortKey="Glendon, Gord" sort="Glendon, Gord" uniqKey="Glendon G" first="Gord" last="Glendon">Gord Glendon</name><name sortKey="Goldberg, Mark S" sort="Goldberg, Mark S" uniqKey="Goldberg M" first="Mark S." last="Goldberg">Mark S. Goldberg</name><name sortKey="Gonzalez Neira, Anna" sort="Gonzalez Neira, Anna" uniqKey="Gonzalez Neira A" first="Anna" last="González-Neira">Anna González-Neira</name><name sortKey="Grenaker Aln S, Grethe" sort="Grenaker Aln S, Grethe" uniqKey="Grenaker Aln S G" first="Grethe" last="Grenaker Aln S">Grethe Grenaker Aln S</name><name sortKey="Grip, Mervi" sort="Grip, Mervi" uniqKey="Grip M" first="Mervi" last="Grip">Mervi Grip</name><name sortKey="Guenel, Pascal" sort="Guenel, Pascal" uniqKey="Guenel P" first="Pascal" last="Guénel">Pascal Guénel</name><name sortKey="Haeberle, Lothar" sort="Haeberle, Lothar" uniqKey="Haeberle L" first="Lothar" last="Haeberle">Lothar Haeberle</name><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A." last="Haiman">Christopher A. Haiman</name><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name><name sortKey="Halverson, Sandra L" sort="Halverson, Sandra L" uniqKey="Halverson S" first="Sandra L." last="Halverson">Sandra L. Halverson</name><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name><name sortKey="Hartikainen, Jaana M" sort="Hartikainen, Jaana M" uniqKey="Hartikainen J" first="Jaana M." last="Hartikainen">Jaana M. Hartikainen</name><name sortKey="Healey, Catherine S" sort="Healey, Catherine S" uniqKey="Healey C" first="Catherine S." last="Healey">Catherine S. Healey</name><name sortKey="Henderson, Brian E" sort="Henderson, Brian E" uniqKey="Henderson B" first="Brian E." last="Henderson">Brian E. Henderson</name><name sortKey="Herrero, Daniel" sort="Herrero, Daniel" uniqKey="Herrero D" first="Daniel" last="Herrero">Daniel Herrero</name><name sortKey="Hillemanns, Peter" sort="Hillemanns, Peter" uniqKey="Hillemanns P" first="Peter" last="Hillemanns">Peter Hillemanns</name><name sortKey="Hollestelle, Antoinette" sort="Hollestelle, Antoinette" uniqKey="Hollestelle A" first="Antoinette" last="Hollestelle">Antoinette Hollestelle</name><name sortKey="Hooning, Maartje J" sort="Hooning, Maartje J" uniqKey="Hooning M" first="Maartje J." last="Hooning">Maartje J. Hooning</name><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name><name sortKey="Humphreys, Keith" sort="Humphreys, Keith" uniqKey="Humphreys K" first="Keith" last="Humphreys">Keith Humphreys</name><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J." last="Hunter">David J. Hunter</name><name sortKey="Jakubowska, Anna" sort="Jakubowska, Anna" uniqKey="Jakubowska A" first="Anna" last="Jakubowska">Anna Jakubowska</name><name sortKey="Jaworska Bieniek, Katarzyna" sort="Jaworska Bieniek, Katarzyna" uniqKey="Jaworska Bieniek K" first="Katarzyna" last="Jaworska-Bieniek">Katarzyna Jaworska-Bieniek</name><name sortKey="John, Esther M" sort="John, Esther M" uniqKey="John E" first="Esther M." last="John">Esther M. John</name><name sortKey="Johnson, Nichola" sort="Johnson, Nichola" uniqKey="Johnson N" first="Nichola" last="Johnson">Nichola Johnson</name><name sortKey="Jukkola Vuorinen, Arja" sort="Jukkola Vuorinen, Arja" uniqKey="Jukkola Vuorinen A" first="Arja" last="Jukkola-Vuorinen">Arja Jukkola-Vuorinen</name><name sortKey="Karina Dieffenbach, Aida" sort="Karina Dieffenbach, Aida" uniqKey="Karina Dieffenbach A" first="Aida" last="Karina Dieffenbach">Aida Karina Dieffenbach</name><name sortKey="Kataja, Vesa" sort="Kataja, Vesa" uniqKey="Kataja V" first="Vesa" last="Kataja">Vesa Kataja</name><name sortKey="Kerin, Michael J" sort="Kerin, Michael J" uniqKey="Kerin M" first="Michael J." last="Kerin">Michael J. Kerin</name><name sortKey="Khusnutdinova, Elza" sort="Khusnutdinova, Elza" uniqKey="Khusnutdinova E" first="Elza" last="Khusnutdinova">Elza Khusnutdinova</name><name sortKey="Knight, Julia A" sort="Knight, Julia A" uniqKey="Knight J" first="Julia A." last="Knight">Julia A. Knight</name><name sortKey="Ko, Yon Dschun" sort="Ko, Yon Dschun" uniqKey="Ko Y" first="Yon-Dschun" last="Ko">Yon-Dschun Ko</name><name sortKey="Koppert, Linetta B" sort="Koppert, Linetta B" uniqKey="Koppert L" first="Linetta B." last="Koppert">Linetta B. Koppert</name><name sortKey="Kosma, Veli Matti" sort="Kosma, Veli Matti" uniqKey="Kosma V" first="Veli-Matti" last="Kosma">Veli-Matti Kosma</name><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name><name sortKey="Kristensen, Vessela" sort="Kristensen, Vessela" uniqKey="Kristensen V" first="Vessela" last="Kristensen">Vessela Kristensen</name><name sortKey="Labreche, France" sort="Labreche, France" uniqKey="Labreche F" first="France" last="Labrèche">France Labrèche</name><name sortKey="Lambrechts, Diether" sort="Lambrechts, Diether" uniqKey="Lambrechts D" first="Diether" last="Lambrechts">Diether Lambrechts</name><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name><name sortKey="Li, Jingmei" sort="Li, Jingmei" uniqKey="Li J" first="Jingmei" last="Li">Jingmei Li</name><name sortKey="Lindblom, Annika" sort="Lindblom, Annika" uniqKey="Lindblom A" first="Annika" last="Lindblom">Annika Lindblom</name><name sortKey="Lindstrom, Sara" sort="Lindstrom, Sara" uniqKey="Lindstrom S" first="Sara" last="Lindstrom">Sara Lindstrom</name><name sortKey="Lissowska, Jolanta" sort="Lissowska, Jolanta" uniqKey="Lissowska J" first="Jolanta" last="Lissowska">Jolanta Lissowska</name><name sortKey="Liu, Jianjun" sort="Liu, Jianjun" uniqKey="Liu J" first="Jianjun" last="Liu">Jianjun Liu</name><name sortKey="Luben, Robert" sort="Luben, Robert" uniqKey="Luben R" first="Robert" last="Luben">Robert Luben</name><name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name><name sortKey="Luccarini, Craig" sort="Luccarini, Craig" uniqKey="Luccarini C" first="Craig" last="Luccarini">Craig Luccarini</name><name sortKey="Mannermaa, Arto" sort="Mannermaa, Arto" uniqKey="Mannermaa A" first="Arto" last="Mannermaa">Arto Mannermaa</name><name sortKey="Manoukian, Siranoush" sort="Manoukian, Siranoush" uniqKey="Manoukian S" first="Siranoush" last="Manoukian">Siranoush Manoukian</name><name sortKey="Maranian, Mel" sort="Maranian, Mel" uniqKey="Maranian M" first="Mel" last="Maranian">Mel Maranian</name><name sortKey="Margolin, Sara" sort="Margolin, Sara" uniqKey="Margolin S" first="Sara" last="Margolin">Sara Margolin</name><name sortKey="Marie Mulligan, Anna" sort="Marie Mulligan, Anna" uniqKey="Marie Mulligan A" first="Anna" last="Marie Mulligan">Anna Marie Mulligan</name><name sortKey="Marme, Frederik" sort="Marme, Frederik" uniqKey="Marme F" first="Frederik" last="Marme">Frederik Marme</name><name sortKey="Mavaddat, Nasim" sort="Mavaddat, Nasim" uniqKey="Mavaddat N" first="Nasim" last="Mavaddat">Nasim Mavaddat</name><name sortKey="Mclean, Catriona" sort="Mclean, Catriona" uniqKey="Mclean C" first="Catriona" last="Mclean">Catriona Mclean</name><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name><name sortKey="Menegaux, Florence" sort="Menegaux, Florence" uniqKey="Menegaux F" first="Florence" last="Menegaux">Florence Menegaux</name><name sortKey="Menendez, Primitiva" sort="Menendez, Primitiva" uniqKey="Menendez P" first="Primitiva" last="Menéndez">Primitiva Menéndez</name><name sortKey="Michailidou, Kyriaki" sort="Michailidou, Kyriaki" uniqKey="Michailidou K" first="Kyriaki" last="Michailidou">Kyriaki Michailidou</name><name sortKey="Miller, Nicola" sort="Miller, Nicola" uniqKey="Miller N" first="Nicola" last="Miller">Nicola Miller</name><name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L." last="Milne">Roger L. Milne</name><name sortKey="Muranen, Taru A" sort="Muranen, Taru A" uniqKey="Muranen T" first="Taru A." last="Muranen">Taru A. Muranen</name><name sortKey="Neuhausen, Susan L" sort="Neuhausen, Susan L" uniqKey="Neuhausen S" first="Susan L." last="Neuhausen">Susan L. Neuhausen</name><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name><name sortKey="Newcomb, Polly" sort="Newcomb, Polly" uniqKey="Newcomb P" first="Polly" last="Newcomb">Polly Newcomb</name><name sortKey="Nielsen, Sune F" sort="Nielsen, Sune F" uniqKey="Nielsen S" first="Sune F." last="Nielsen">Sune F. Nielsen</name><name sortKey="Nord, Silje" sort="Nord, Silje" uniqKey="Nord S" first="Silje" last="Nord">Silje Nord</name><name sortKey="Nordestgaard, B Rge G" sort="Nordestgaard, B Rge G" uniqKey="Nordestgaard B" first="B Rge G." last="Nordestgaard">B Rge G. Nordestgaard</name><name sortKey="Offit, Kenneth" sort="Offit, Kenneth" uniqKey="Offit K" first="Kenneth" last="Offit">Kenneth Offit</name><name sortKey="Olson, Janet E" sort="Olson, Janet E" uniqKey="Olson J" first="Janet E." last="Olson">Janet E. Olson</name><name sortKey="Orr, Nick" sort="Orr, Nick" uniqKey="Orr N" first="Nick" last="Orr">Nick Orr</name><name sortKey="Pankratz, Vernon S" sort="Pankratz, Vernon S" uniqKey="Pankratz V" first="Vernon S." last="Pankratz">Vernon S. Pankratz</name><name sortKey="Park Simon, Tjoung Won" sort="Park Simon, Tjoung Won" uniqKey="Park Simon T" first="Tjoung-Won" last="Park-Simon">Tjoung-Won Park-Simon</name><name sortKey="Pensotti, Valeria" sort="Pensotti, Valeria" uniqKey="Pensotti V" first="Valeria" last="Pensotti">Valeria Pensotti</name><name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name><name sortKey="Peto, Julian" sort="Peto, Julian" uniqKey="Peto J" first="Julian" last="Peto">Julian Peto</name><name sortKey="Pharoah, Paul D P" sort="Pharoah, Paul D P" uniqKey="Pharoah P" first="Paul D. P." last="Pharoah">Paul D. P. Pharoah</name><name sortKey="Pilar Zamora, M" sort="Pilar Zamora, M" uniqKey="Pilar Zamora M" first="M." last="Pilar Zamora">M. Pilar Zamora</name><name sortKey="Pita, Guillermo" sort="Pita, Guillermo" uniqKey="Pita G" first="Guillermo" last="Pita">Guillermo Pita</name><name sortKey="Prokofyeva, Darya" sort="Prokofyeva, Darya" uniqKey="Prokofyeva D" first="Darya" last="Prokofyeva">Darya Prokofyeva</name><name sortKey="Pylk S, Katri" sort="Pylk S, Katri" uniqKey="Pylk S K" first="Katri" last="Pylk S">Katri Pylk S</name><name sortKey="Radice, Paolo" sort="Radice, Paolo" uniqKey="Radice P" first="Paolo" last="Radice">Paolo Radice</name><name sortKey="Rafiq, Sajjad" sort="Rafiq, Sajjad" uniqKey="Rafiq S" first="Sajjad" last="Rafiq">Sajjad Rafiq</name><name sortKey="Rahman, Nazneen" sort="Rahman, Nazneen" uniqKey="Rahman N" first="Nazneen" last="Rahman">Nazneen Rahman</name><name sortKey="Rau Murthy, Rohini" sort="Rau Murthy, Rohini" uniqKey="Rau Murthy R" first="Rohini" last="Rau-Murthy">Rohini Rau-Murthy</name><name sortKey="Reed, Malcolm W R" sort="Reed, Malcolm W R" uniqKey="Reed M" first="Malcolm W. R." last="Reed">Malcolm W. R. Reed</name><name sortKey="Renwick, Anthony" sort="Renwick, Anthony" uniqKey="Renwick A" first="Anthony" last="Renwick">Anthony Renwick</name><name sortKey="Robson, Mark" sort="Robson, Mark" uniqKey="Robson M" first="Mark" last="Robson">Mark Robson</name><name sortKey="Rosario Alonso, M" sort="Rosario Alonso, M" uniqKey="Rosario Alonso M" first="M." last="Rosario Alonso">M. Rosario Alonso</name><name sortKey="Rudolph, Anja" sort="Rudolph, Anja" uniqKey="Rudolph A" first="Anja" last="Rudolph">Anja Rudolph</name><name sortKey="Rutgers, Emiel J" sort="Rutgers, Emiel J" uniqKey="Rutgers E" first="Emiel J." last="Rutgers">Emiel J. Rutgers</name><name sortKey="Sanchez, Marie" sort="Sanchez, Marie" uniqKey="Sanchez M" first="Marie" last="Sanchez">Marie Sanchez</name><name sortKey="Sawyer, Elinor J" sort="Sawyer, Elinor J" uniqKey="Sawyer E" first="Elinor J." last="Sawyer">Elinor J. Sawyer</name><name sortKey="Schmidt, Marjanka K" sort="Schmidt, Marjanka K" uniqKey="Schmidt M" first="Marjanka K." last="Schmidt">Marjanka K. Schmidt</name><name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K." last="Schmutzler">Rita K. Schmutzler</name><name sortKey="Schneeweiss, Andreas" sort="Schneeweiss, Andreas" uniqKey="Schneeweiss A" first="Andreas" last="Schneeweiss">Andreas Schneeweiss</name><name sortKey="Schoemaker, Minouk J" sort="Schoemaker, Minouk J" uniqKey="Schoemaker M" first="Minouk J." last="Schoemaker">Minouk J. Schoemaker</name><name sortKey="Schumacher, Fredrick" sort="Schumacher, Fredrick" uniqKey="Schumacher F" first="Fredrick" last="Schumacher">Fredrick Schumacher</name><name sortKey="Schurmann, Peter" sort="Schurmann, Peter" uniqKey="Schurmann P" first="Peter" last="Schürmann">Peter Schürmann</name><name sortKey="Scott, Rodney" sort="Scott, Rodney" uniqKey="Scott R" first="Rodney" last="Scott">Rodney Scott</name><name sortKey="Seal, Sheila" sort="Seal, Sheila" uniqKey="Seal S" first="Sheila" last="Seal">Sheila Seal</name><name sortKey="Seibold, Petra" sort="Seibold, Petra" uniqKey="Seibold P" first="Petra" last="Seibold">Petra Seibold</name><name sortKey="Seynaeve, Caroline" sort="Seynaeve, Caroline" uniqKey="Seynaeve C" first="Caroline" last="Seynaeve">Caroline Seynaeve</name><name sortKey="Shah, Mitul" sort="Shah, Mitul" uniqKey="Shah M" first="Mitul" last="Shah">Mitul Shah</name><name sortKey="Sigurdson, Alice J" sort="Sigurdson, Alice J" uniqKey="Sigurdson A" first="Alice J." last="Sigurdson">Alice J. Sigurdson</name><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name><name sortKey="Slager, Susan" sort="Slager, Susan" uniqKey="Slager S" first="Susan" last="Slager">Susan Slager</name><name sortKey="Sohn, Christof" sort="Sohn, Christof" uniqKey="Sohn C" first="Christof" last="Sohn">Christof Sohn</name><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C." last="Southey">Melissa C. Southey</name><name sortKey="Stegmaier, Christa" sort="Stegmaier, Christa" uniqKey="Stegmaier C" first="Christa" last="Stegmaier">Christa Stegmaier</name><name sortKey="Sutter, Christian" sort="Sutter, Christian" uniqKey="Sutter C" first="Christian" last="Sutter">Christian Sutter</name><name sortKey="Swann, Ruth" sort="Swann, Ruth" uniqKey="Swann R" first="Ruth" last="Swann">Ruth Swann</name><name sortKey="Swerdlow, Anthony" sort="Swerdlow, Anthony" uniqKey="Swerdlow A" first="Anthony" last="Swerdlow">Anthony Swerdlow</name><name sortKey="Takhirova, Zalina" sort="Takhirova, Zalina" uniqKey="Takhirova Z" first="Zalina" last="Takhirova">Zalina Takhirova</name><name sortKey="Tamimi, Rulla M" sort="Tamimi, Rulla M" uniqKey="Tamimi R" first="Rulla M." last="Tamimi">Rulla M. Tamimi</name><name sortKey="Tapper, William J" sort="Tapper, William J" uniqKey="Tapper W" first="William J." last="Tapper">William J. Tapper</name><name sortKey="Tessier, Daniel C" sort="Tessier, Daniel C" uniqKey="Tessier D" first="Daniel C." last="Tessier">Daniel C. Tessier</name><name sortKey="Titus, Linda" sort="Titus, Linda" uniqKey="Titus L" first="Linda" last="Titus">Linda Titus</name><name sortKey="Toland, Amanda E" sort="Toland, Amanda E" uniqKey="Toland A" first="Amanda E." last="Toland">Amanda E. Toland</name><name sortKey="Tollenaar, Robert A E M" sort="Tollenaar, Robert A E M" uniqKey="Tollenaar R" first="Robert A. E. M." last="Tollenaar">Robert A. E. M. Tollenaar</name><name sortKey="Tomlinson, Ian" sort="Tomlinson, Ian" uniqKey="Tomlinson I" first="Ian" last="Tomlinson">Ian Tomlinson</name><name sortKey="Torres, Diana" sort="Torres, Diana" uniqKey="Torres D" first="Diana" last="Torres">Diana Torres</name><name sortKey="Trentham Dietz, Amy" sort="Trentham Dietz, Amy" uniqKey="Trentham Dietz A" first="Amy" last="Trentham-Dietz">Amy Trentham-Dietz</name><name sortKey="Truong, Therese" sort="Truong, Therese" uniqKey="Truong T" first="Thérèse" last="Truong">Thérèse Truong</name><name sortKey="Tsimiklis, Helen" sort="Tsimiklis, Helen" uniqKey="Tsimiklis H" first="Helen" last="Tsimiklis">Helen Tsimiklis</name><name sortKey="Turnbull, Clare" sort="Turnbull, Clare" uniqKey="Turnbull C" first="Clare" last="Turnbull">Clare Turnbull</name><name sortKey="Tyrer, Jonathan" sort="Tyrer, Jonathan" uniqKey="Tyrer J" first="Jonathan" last="Tyrer">Jonathan Tyrer</name><name sortKey="Ulmer, Hans Ulrich" sort="Ulmer, Hans Ulrich" uniqKey="Ulmer H" first="Hans-Ulrich" last="Ulmer">Hans-Ulrich Ulmer</name><name sortKey="Vachon, Celine" sort="Vachon, Celine" uniqKey="Vachon C" first="Celine" last="Vachon">Celine Vachon</name><name sortKey="Van Asperen, Christi J" sort="Van Asperen, Christi J" uniqKey="Van Asperen C" first="Christi J." last="Van Asperen">Christi J. Van Asperen</name><name sortKey="Van Den Ouweland, Ans M W" sort="Van Den Ouweland, Ans M W" uniqKey="Van Den Ouweland A" first="Ans M. W." last="Van Den Ouweland">Ans M. W. Van Den Ouweland</name><name sortKey="Van Limbergen, Erik" sort="Van Limbergen, Erik" uniqKey="Van Limbergen E" first="Erik" last="Van Limbergen">Erik Van Limbergen</name><name sortKey="Van Ongeval, Chantal" sort="Van Ongeval, Chantal" uniqKey="Van Ongeval C" first="Chantal" last="Van Ongeval">Chantal Van Ongeval</name><name sortKey="Verhoef, Senno" sort="Verhoef, Senno" uniqKey="Verhoef S" first="Senno" last="Verhoef">Senno Verhoef</name><name sortKey="Vijai, Joseph" sort="Vijai, Joseph" uniqKey="Vijai J" first="Joseph" last="Vijai">Joseph Vijai</name><name sortKey="Vincent, Daniel" sort="Vincent, Daniel" uniqKey="Vincent D" first="Daniel" last="Vincent">Daniel Vincent</name><name sortKey="Wang Gohrke, Shan" sort="Wang Gohrke, Shan" uniqKey="Wang Gohrke S" first="Shan" last="Wang-Gohrke">Shan Wang-Gohrke</name><name sortKey="Wang, Qin" sort="Wang, Qin" uniqKey="Wang Q" first="Qin" last="Wang">Qin Wang</name><name sortKey="Whittemore, Alice S" sort="Whittemore, Alice S" uniqKey="Whittemore A" first="Alice S." last="Whittemore">Alice S. Whittemore</name><name sortKey="Wildiers, Hans" sort="Wildiers, Hans" uniqKey="Wildiers H" first="Hans" last="Wildiers">Hans Wildiers</name><name sortKey="Winqvist, Robert" sort="Winqvist, Robert" uniqKey="Winqvist R" first="Robert" last="Winqvist">Robert Winqvist</name><name sortKey="Yang, Rongxi" sort="Yang, Rongxi" uniqKey="Yang R" first="Rongxi" last="Yang">Rongxi Yang</name><name sortKey="Yannoukakos, Drakoulis" sort="Yannoukakos, Drakoulis" uniqKey="Yannoukakos D" first="Drakoulis" last="Yannoukakos">Drakoulis Yannoukakos</name><name sortKey="Yao, Song" sort="Yao, Song" uniqKey="Yao S" first="Song" last="Yao">Song Yao</name><name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name><name sortKey="Ziogas, Argyrios" sort="Ziogas, Argyrios" uniqKey="Ziogas A" first="Argyrios" last="Ziogas">Argyrios Ziogas</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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